AbstractBackground: Amitraz is a pharmaceutical, veterinary, and agricultural product which is used worldwide under numerous generic names as an acaricide and insecticide. Because of its widespread use, Amitraz has emerged as one of the common poisoning in rural areas. Aims and Methods: To report the clinical features, laboratory findings and the management instituted for the patients with acute Amitraz Poisoning and review the previously reported cases. Results: Total sixteen (Ten male and six female) patients aged between17 to 48years were admitted to our department. The ingested amount was ranging from 15 ml to 30 ml.The initial signs and symptoms were impaired consciousness, drowsiness, vomiting,disorientation, miosis, mydriasis, hypotension, hypertension, tachycardia, bradycardia, tachypnea, bradypnoea, and hypothermia. Six patients required mechanical ventilation. CNS depression resolved spontaneously within 8–48 hours in all. The length of hospital stay was three to sevendays; all the patientsrecovered Conclusion: Amitraz is a deadly poison with mainly central nervous system and respiratory system depression, without any antidote. Early and aggressive management helps in excellent patient outcome in the form ofcomplete recovery. Public awareness isrequired to prevent poisoning by such compound, especially among the illiterate farmers.