AbstractContext: Use of bioprosthetic valves instead of mechanical valves is increasing even in young patients apparently because of its advantages. Aims: We aimed to report a single centre experience of bioprosthetic valvular replacement and the complications in Western Indians. Settings & Design: Prospective, observational. Methods & Material: We have enrolled 54 patients undergoingAVR using biological valve implantation from May 2012 to April 2016 in a Medical college at Ahmedabad, Gujarat. Demographic, clinical and operative details of the patients were collected. Statistical Analysis Used: The statistical calculations were performed using SPSS software v 20.0 (Chicago, IL, USA) Quantitative data was expressed as mean±SD whereas qualitative data was expressed as percentage. Kaplan Meier was performed to assess survival of the population. Results: Overall 22.22% mortality was observed in the study cohort. The probability of freedom from a survival event at 5 years was 77.8% for patients with mitral valve bio prosthetic replacement. Postoperative complications observed were tachyarrhythmia 4 (7.4%), reexploration 4 (7.4%), hemolysis 1 (1.85%) congenital cardiac failure 4 (7.4%), structural valve degeneration 8 (14.8%) and thromboembolism 4 (7.4%) in postoperative complication. Conclusions: In the present report, AVR with bioprosthetic valve for patients <70 years old was associated with a low reoperation rate, postoperative complications and higher survival.