Adipose tissues or adipocytes releases signaling proteins called adipokines. Certain adipokines appear to have cardio protective function against myocardial ischaemia/ reperfusion (I/R) injury while others participate in cardiac remodeling. Visfatin also known as nicotinamide phosphoribosyl- transferase, is a cytokine that is highly expressed in visceral fat. The involvement of the levels of this adipokine in cardiovascular disease is still controversial. Similarly low concentration of vaspin levels is associated with the severity of coronary artery disease.The aim of our study was to identify the concentration of the adipokines visfatin and vaspin in patients with coronary artery disease across the spectrum of the disease. A significant difference was observed in visfatin concentration between STEMI and NSTEMI patients. Similarly when vaspin concentration was compared, a remarkable difference was observed between STEMI and NSTEMI groups. There was a significant correlation between vaspin and Left ventricular ejection fraction. In conclusion, visfatin and vaspin concentration are elevated in acute myocardial infarction and could be involved in the pathogenesis of coronary artery disease. More fundamental research on the role of these adipokines in the pathophysiology of the disease is warranted.