Abstract The present study was carried out to isolate the etiological agent responsible for an outbreak of pneumonia causing mortality in young lambs. The outbreak was occurred during November 2017 in a sheep flock in Maddakkatta village of peddara mandal in Prakasam district from Andhra Pradesh. Affected animals were clinically examined, nasal swabs and blood samples collected from live animals, whereas heart, liver and lung tissues collected during postmortem. The etiological agent was isolated and identified as Streptococcus pneumoniae on conventional bacteriological and biochemical methods. The antibiogram of the Streptococcus pneumoniae isolates revealed that the isolates were sensitive to Norfloxacin followed by ceftriaxone erythromycin and resistant to penicillin, tetracycline, Enrofloxacin and ciprofloxacin etc. The serum biochemical profile resulted in decrease in serum concentration of albumin, A/G ratio and increased level of total protein , globulins, Blood Urea Nitrogen(BUN), creatinine and serum enzymatic activities of ALT and AST supports the pneumoniae of bacterial origin implicating different degrees of organs dysfunction caused by the disease condition
Keywords: Streptococcus Pneumoniae; Bacteriological Isolation; Biochemical Studies; Antibiotic Sensitivity Test