AbstractThere is an increase in demand for food of animal origin, due to increasing global population. Therefore, livestock owners around the globe are trying to increase animal product output which ultimately leads to enormous production pressure on the livestock. To achieve such high production goals, animals should be disease free and physiologically fit. To ensure their healthy status, antibiotics are being used extensively in therapeutic & subtherapeutic doses to enhance production, which ultimately lead to presence of antibiotic residues in the final animal products like milk, meat, eggs etc. If such contaminated products are consumed by humans for a longer period of time, it may subsequently lead to significant health and economic issues ranging from emergence of AMR to starter failure in dairy industry. Therefore, present review focuses on various aspects of antibiotic usage in animal husbandry practices, initiative taken to combat AMR, methods used for detection of antibiotics in milk and their impact on human health.