Objectives: To compare the intubating conditions, clinical duration of action, cardiovascular responses, side effects associated with administration of rocuronium bromide 0.9mg/kg and succinylcholine chloride 1mg/kg for rapid sequence intubation. Study Design: Randomized controlled clinical trial. Place and Duration of the study: Rajah Muthiah Medical College, Chidambaram 201617. Methodology: After obtaining approval from institutional ethics committee and written informed consent from all patients, a randomized controlled double blinded clinical trial was conducted on 60 ASA I and II adult patients undergoing elective surgeries. Patients were randomly allocated into two groups group S and group R of 30 each. Patients in group S were to receive succinylcholine chloride 1 mg/kg and group R rocuronium bromide 0.9 mg/kg and intubation attempted at 60 seconds. Haemodynamic variables (heart rate, systolic, diastolic and mean arterial pressures) were recorded. Intubating conditions were graded using the score adopted by Toni Magorian et al [1]., and compared using Pearson’s Chisquare test. Conclusion: Rocuronium bromide 0.9mg/kg is a safe alternative to succinylcholine chloride 1mg/kg for rapid sequence intubation in adult patients in situations where succinylcholine chloride is contraindicated and where there is no anticipated difficult airway.