Background: Premedication is used to provide sedation and anxiolysis and to enhance the quality of induction, maintenance and recovery from anaesthesia. The present study was carried out to study the pressor responses to laryngoscopy and intubation during induction with ketamine and scoline, using prior diazepam and clonidine as premedication. Method: A total of 60 normotensive patients of ASA grade I of both genders, aged 20 to 50 years, were randomized for this prospective study and divided into two groups of 30 patients each. Group I patients received Tab. Diazepam 0.2 mg/kg body weight and Group II patients received Tab. Clonidine 3 microgram/kg body weight. Both groups were assessed for changes in pulse rate, blood pressure and sedation. Scoring was taken every 15 minutes after giving this medication till induction. Result: The pulse rate rise, systolic blood pressure and diastolic blood pressure were more in control group as compared to clonidine group. There was statistically significant difference between mean pulse rate change, systolic blood pressure and diastolic blood pressure of both the groups during 1st min of intubation. And also there was significant difference between the two groups for sedation score (p<0.001) and pain score (p<0.001). Conclusion: Oral clonidine premedication 3 microgram/kg body weight given 90 minutes prior to induction of anaesthesia with ketamine is an effective and safe method for controlling the rise in pulse rate and rise in blood pressure associated with laryngoscopy and intubation. It also gives adequate analgesia in the immediate postoperative period without undue sedation.