Introduction: There are three classical stages in the control of gastric secretion, which are mediated by short myenteric reflexes and long vagal reflexes and by systemic hormone secretion. More recently the role of local peptides in modulating secretion and motility has become evident. Methodology: With simple random sampling technique, 60 patients were selected who fulfil the inclusion criteria and exclusion criteria and divided them into two groups of 30 each.Group P: received intravenous pantoprazole 40 mg i.v.Group E: received intravenous esomeprazole 40 mg i.v. Results: Among the group P the mean gastric aspirate volume was 9.56±2.52 ml, and in group E mean gastric aspirate volume was 5.66±2.36 ml, which was statistically lower in group E as compared to group P. Conclusion: Esomeprazole reduced the volume of gastric juice to < 6ml and pantoprazole < 10 ml