Background and Objective: Total intravenous anaesthesia currentlypracticed during short surgical process.Propofol due to its favourable pharmacokinetic profile is widely used in TIVA butlacks analgesic property, decreased cardiac index and pain on injection. To overcome these disadvantage we added ketamine in Group K and butorphanol in Group B for TIVA technique for comparative study. Methods: We studied 60 patients of either sex aged 18-60yrs of ASA-I and II grade, undergoing short surgical procedures less than one hour. They were randomly allocated into 2 groups, group K, receiving ketamine 1mg/kg and propofol 1.5mg/kg and group B received butorphanol 20 g/kg and propofol 1.5mg / kg as inducing agent Anaesthesia was maintained with propofo l9mg/kg/hr via infusion pump in both group. Baseline, intra and postoperative haemodynamic parameters, sedation, postoperative nausea, vomiting were evaluated every 10min interval upto 40 minutes. Pain on injection with propofolwas also noted. Data recorded andanalysed by t-test, chisquare and F test. Results and Observation: Significant variation was observed in hemodynamic parameter in Group B whereas no statistically significant change in group K. The incidence of postoperative sedation was 36.7% in Group K whereas in group B it was 46.7%. Attenuation of pain on injection with propofol, was 23.3% in group B as compared with 56.7% in group K showing pain.There was no statistically significant difference in two groups regarding incidence of PONV. Interpretation and conclusion: We concluded thatPropofol-ketamine, offered better haemodynamic stability over propofol-butorphanol. Pain on injection was better attenuated by butorphanol. Post operative sedation was more with butorphanol. No significant difference in PONV between two groups.