Background and Aim: For several decades, suxamethonium was the gold standard relaxant for rapid sequence intubation. However, the unintended side-effects such as muscle fasciculation, hyperkalemia, rise in intracranial and intraocular pressures led to the search of newer relaxants. In this study we compared the most recent rocuronium and cisatracurium at a dose as regard the onset of action, intubating conditions, efficacy, and safety during general anesthesia for adult gynecological ambulatory surgery. Materials & Methods: Total of 90 patients were randomly selected and included in the present study. The age range for the patient was found to be 25 to 65 years. All the included patients were randomly divided into two groups, 45 patients in each group. In the first group Rocuronium 0.6 mg/kg was administered and in other group 0.1 mg/kg was administered. Results: The time to achieve maximum blockade was 160.4 sec and 85.94 sec respectively in Group A and Group B. The clinical duration was found to be 48.9 mins and 32.8 min respectively in group A and B. Total intubation score achieved at 60 secs was 6.36 and 8.12 seconds respectively for group A and group B. Conclusion: Rocuronium has a rapid onset of action with good intubating conditions, Cisatracurium has an intermediate duration of action, and both are potent and safe with excellent cardiovascular stability and without apparent histamine release.