Background: Osteoarthritis (OA) is the second most common rheumatologic problem and it is the most frequent joint disease with a prevalence of 22% to 39% in India. Incapacitating the patients and compromising the quality of life. Conservative treatments may not be effective always, and that some of them have serious adverse effects. Various surgical methods have been used to treat OA. Genicular nerve neurotomy is currently being evaluated for the treatment of chronic knee pain due to Osteoarthritis. Aim and Objectives: The study was aimed to evaluate the efficacy of single radiofrequency thermocoagulation (RFT) of the knee joint with the objective to compare the success rates at the end of first, third and sixth month and to study the complications. Materials and Methods: A total number of 88 patients were included in the study of age ranging from 40 to 80 years of age from Jan. 2016 to Dec. 2016. The patients with knee pain of more than 6 months and not responding to the conventional line of treatment, were included in the study. Two groups, 44 each group, were made depending on the severity of osteoarthritis changes of knee joint on X- ray findings of the knee joint. After diagnostic blocks was given to all of the patients and on satisfactory pain control RFTC was done. Pain score was assessed immediately after the procedure, while discharge i.e. two hrs after the procedure, 2nd day on telephonic call, 1 week, 4 week and 12 week and 6 months. Results: Out of 88 patients 50 (56.81%) were males and 38 (43.18%) females included in the study. Majority of the patients 36 (40.90%) tried analgesic drugs for pain relief and 27 (30.68%) patients tried analgesic drugs + physical therapy + intra-articular injection prior to RFT treatment. At the 3rd-month follow-up, 73 (82.95%) patients were pain-free and at the end of 6 months, 62 (70.45%) were pain-free. There was no significant statistical difference between both groups at the end of 6 months. Conclusion: It was concluded that PRF, applied to the knee joint of patients suffering from chronic knee pain due to OA and not responding to the conservative treatment methods sufficiently, seems to be an effective and safe method.