Comparative efficacy of general anesthesia versus spinal anesthesia for laparoscopic cholecystectomy. Objective: The aim was to compare general anaesthesia and spinal anesthesia in patients undergoing cholecystectomy evaluating intraoperative hemodynamic parameters, Post Operative analgesic and side effects. Method: A double blind study was conducted on 50 ASA grade I, II and III patients who received spinal anesthesia in group 1 (N=25) and general anesthesia in group II (N=25). Assessment of the block, vital monitoring and complications were noted. Results: No significant differences were observed in both the groups hypotension, bradycardia were more frequent in patients those who underwent spinal anesthesia. Satisfaction was similar in both groups. Conclusion: General Anesthesia is a better choice for laparoscopic cholecystectomy. Nevertheless in respiratory compromised patients, Spinal Anesthesia is a better choice.