Aims and Objectives: The present study was conducted to know the efficacy of dexmedetomedine infusion on perioperative hemodynamics and reduction in anesthetic requirement during general anesthesia in spine surgeries. Materials and Methods: After obtaining institutional ethical committee approval, the study was undertaken at Mahadevappa Rampure Medical College, Gulbarga. After obtaining informed written consent, 60 patients of ASA grade 1 & 2 were randomly allocated into two groups of 30 patients each,as Group C and Group D. The age group was 20­60 years of either sex undergoing elective spine surgery under GA. In group D, patients received dexmedetomidine as 1µg/kg over 10min before induction of anesthesia and maintained with 0.5­0.7µg /kg/hr infusion during anesthesia, and group C was taken as control. Hemodynamic changes and anesthetic requirement were recorded perioperatively. Results: Dexmedetomedine causes significant reduction in heart rate and mean arterial pressure, blunted tachycardia and hypertensive response to intubation and extubation (p<0.05), maintained better hemodynamic intraopertively. Also it reduced the requirement of fentanyl(50%), and inhalational agent isoflurane (29­33%) during general anesthesia. Conclusion: Dexmedetomedine reduces the requirement of opioids and inhalational agent during general anesthesia and provide stable hemodynamics intraoperatively.

Keywords:Dexmedetomedine; Fentanyl; General Anesthesia; Isoflurane.