Background and Aim: Studies and research are ongoing to find appropriate adjuvants tointrathecal local anaesthetic agents to make them more effective and economical. In view of the same we undertook a study with Levobupivacaine,being a newer agent with more cardiac stability and compared the outcomes with 3 adjuvants. Settings and Design: After approval from the hospital ethical committee, a randomized double blind study was conducted among 90 healthy, American Society of Anesthesiologists ASA I and II patients, scheduled forlower limb surgeries.The study wasdone over a period of one year. Materials and Methods: Spinal block was administered in L3 and L4 intervertebral space, using 0.5% Levobupivacaine 12mg. Adjuvants added in group 1­ Fentanyl 25 mcg, in group 2­ Dexmedetomidine 10mcg and in group 3 ­ Clonidine 30mcg. Anaesthetic level achieved was T10. Onset time to achieve sensory, motor blockade, and their regression time was noted. Hemodynamic changes and requirement for other analgesic drugs was also noted. Results: 90 patients were enrolled in our study. The data was recorded and analysed using statistical analysis.Conclusion: To conclude, Levobupivacaine with Dexmedetomidine, gavebetter result for intra and postoperativeregionalanaesthesia without any adverse effects.

Keywords: Adjuvants; Intrathecal; Levobupivacaine; Dexmedetomidine; Fentanyl; Clonidine.