Neonatal septicaemia is a major cause of morbidity and mortality in new born infants. Back ground and objectives: to study the incidence, predisposing factors, clinical profile, out come, early indicators of correlation with all clinical aspects and antibiotic sensitivity pattern of neonatal septicaemia. Materials and Methods: The 50 neonates who are showing the well documented signs of septicaemia are included in this study. Results: culture was bacteriologically positive in 34% cases. Ciprofloxacin had maximum sensitivity 88.2%. Leucopoenia 5000/cmm had sensitivity of 47% specificity of 66.67% and ppa of 42.11%,toxic granulation had 70.56% sensitivity, 63.65% specificity and 50% ppa. B/n>0.2 had 88.2% sensitivity 62.4% ppa. Mesr had sensitivity of 70.56%, specificity of 84.84%, ppa of 70.5%, creactive protein had 88.2% sensitivity and 87.8% specificity and 78.95%ppa. Case fatality rate was 28%. Conclusion: Clinical features of neonatal septicaemia are non specific and vague. Sepsis screen had good sensitivity, specificity and ppa. combination of tests increase the specificity and ppa. An an individual test creactive protein has highest sensitivity.

Keywords: Neonates; Septicaemia; Outcome.