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DOI: http://dx.doi.org/10.21088/ija.2320.0022.6217.31

Abstract

Pathoanatomical examination procedures such as epidermal nerve fiber density (ENFD) was indicative of small-fiber dysfunction and the objective of this short communication was to throw light on ENFD and its use in assessment and treatment of peripheral neuropathies. Limited yet sufficient evidence shows that ENFD had established normative reference range, predictive equation with respect to age and gender, low inter-measurement variability; and was correlated to quantitative sensory test measures, morphometry, pain-related evoked potentials and C-fiber axon reflex flare size; was used in HIV-related peripheral neuropathy, sensory ganglionopathiesand Diabetic peripheral neuropathy; and, was influenced by topical treatments such as capsaicin and lidocaine patches. Thus ENFD is the one of earliest indicator of nerve function and dysfunction in peripheral nerve disorders.

Keywords: Neuroanatomy; Neurohistology; Skin Biopsy; Peripheral Neuropathy.  

Corresponding Author : Senthil P. Kumar, Professor and Head, Department of Physiotherapy, School of Allied Health Science and Research, Sharda University, Plot No. 32-34, Knowledge Park III, Greater Noida, Uttar Pradesh 201306