Introduction: Multiple genes determine fingerprint configuration and the study of fingerprints reveal vital genetic and medical information about an individual. Any deviation in dermatoglyphics pattern indicates a genetic difference between control group and pathological population [2] .Chewing of guthka containing areca nut and tobacco is an important risk factor for oral submucus fibrosis (OSMF) but the non chewers are also developing OSMF.Genetic predisposition explains such occurrence of OSMF with or without habits of chewing guthka containing areca nut. Aims: This study was aimed to search for a dermatoglyphic marker that will be helpful to identify predisposition of a person with guthka chewing habits for developing OSMF Objectives: To find any statistically significant variation in fingertip patterns of chronic guthka chewers in pathologic group with development of OSMF and control group without development of OSMF Material and Methods: The control group A: were subjects with history of guthka chewing habit without clinical OSMF. The study group B: Patients with clinically diagnosed OSMF with history of guthka chewing habits were from routine ENT OPD patients at SRTR Govt. medical college and Rolled prints of palm and fingers of right and left hands of all subjects were taken and analyzed following standard methods of Cummins and Midloe. Result: When individual digit wise split up of fingertip patterns from both the hands were compared in pathologic and control group statistically significant differences were observed in distribution of fingertip patterns in group A and group B.Conclusion: Individual digit wise distribution of fingertip patterns can be used to determine the predisposition of a person with guthka chewing habits to develop OSMF

Keywords: Fingertip Patterns; Oral Submucus Fibrosis; Gutkha Chewing