Normal level of thyroid hormones is important for normal hepatic function and thyroid abnormality may affect the metabolic functions of the liver. The aim of the study was to determine the biochemical markers (especially enzymes and proteins) of Liver Function Test (LFT) in patients with hypothyroidism and their possible correlation with thyroid profile. Materials and Methods: Thyroid profile and liver function tests (LFT) were evaluated in 60 primary hypothyroid cases and compared it with age matched normal euthyroid controls after applying exclusion criteria. Fasting venous sample was used for analyzing the parameters. Statistical analysis was done using Students ’t’ test. Pearson’s correlation coefficient test was done to establish the relationships between the parameters. Results and Observations: Subjects with primary hypothyroidism had significantly raised serum AST, ALT, ALP and total protein levels when compared to controls. Conclusion: Primary hypothyroidism is associated with significant derangement in biochemical parameters of liver function. Hence, liver function tests should be regularly monitored in primary hypothyroid patients.

Keywords: Hypothyroidism; Liver Enzymes; Total Proteins.