Objectives of the Study: 1. To assess the pretest knowledge regarding organ donation among the students of arts and science. 2. To assess the posttest knowledge regarding organ donation among the students of arts and science. 3. To compare the effectiveness of pretest and posttest level of knowledge among the students of arts and science. 4. To associate the knowledge regarding organ donation with selected demographic variables. Methodology: Research Design: Preexperimental one group pre and post test design. Setting of Study: Padmashree Institute management sciences. Population: Arts and sciences students. Sample: 40 Art students. Sampling Technique: Simple random sampling technique by using lottery method. Description of the tool: A) Demographic variables. B) structure questionnaire Used to assess the awareness. Data Analysis: Descriptive and inferential statistics were used. Major Findings of the Study: Majority of the subjects (87.5%) 35 in the age group of 21 years and above. Regarding information on organ donation 36 (90%) had heard information on organ donation trough Television, New paper, Radio. Regarding blood donated 14 (35%) had donated blood. The study results shows that 75% of them were had moderate knowledge, 17.5% subjects were had adequate knowledge and 7.5% subjects were had inadequate knowledge in pretest. Whereas after administration of SIM 37.5% subjects were had moderate knowledge, 60% subjects were had adequate knowledge and 2.5 % subjects were had inadequate knowledge. It shows the after administration of SIM majority of the subjects had improved the knowledge regarding organ donation. Conclusion: The present study revealed that majority of the subjects had moderate knowledge regarding organ donation. Whereas after administration Self Instructional modules majority of subjects had adequate knowledge on organ donation. Study concluded that the Arts and sciences and young students were to educate to understand the importance of organ donation, and come forward to donate organ.