The Pandemic H1N1/09 virus is a swine origin Influenza A virus subtype H1N1 virus strain responsible for the 2009 flu pandemic. The influenza virus has characteristics of antigenic variation due to antigenic shift and drift.The human race does not have immunity against this new reassorted and novel virus that is why it has potential to spread world wide. Epidemic started in Mexico in March, 2009 spread to whole of world within two months time.As of 24 May 2010, 10193 cases of swine flu have been confirmed with 1035 deaths.With evidence on the effectiveness of vaccination in the control and prevention of seasonal influenza, vaccination for pandemic influenza is one of the most important primary preventive measures to reduce the disease burden associated with influenza A (H1N1) infection. Several high risk groups have been identified as "the priority group" to receive the influenza A (H1N1) vaccination and among these, healthcare workers have been identified"as a first priority" to be vaccinated against influenza A (H1N1) by the World Health Organization.Also previous studies that have examined the acceptability of seasonal influenza vaccination among healthcare workers and found low acceptability. The willingness of the healthcare workers to accept the H1N1 vaccination needs to be assessed. Not only the willingness but their fears about vaccination must be known so that they can be further educated on vaccine and a good compliance can be obtained.