Aim of the Study: To evaluate solitary thyroid nodules clinically, to study the role of FNAC in these lesions, and to correlate clinical findings with cytology and histopathology.

Materials and Methods: This was a prospective study done over a period of two years, in the department of General Surgery, Kakatiya Medical College, MGM Hospital, Warangal, Telangana. A total of 110 patients were included in the study. Clinical examination, cytology and histopathology findings were correlated.

Results: Age of the patients ranged from 11 to 68 years and the male to female ratio was 1:2.6. Majority of cases were seen in the fourth decade. After comparison of results of FNAC with histopathology, FNAC showed overall diagnostic accuracy of 89.8% with specificity of 100%, sensitivity of 50% for malignant lesions, positive predictive value of 100 % for malignancy and negative predictive value of 88.7%.

Conclusion: Solitary thyroid nodules are more common in the fourth decade of life and have a female preponderance. Fine needle aspiration cytology of these lesions has a good overall diagnostic accuracy of almost 90% but is less sensitive in detecting malignant lesions. FNAC is a very useful procedure for assessment of solitary Thyroid nodules especially in conjunction with complete clinical evaluation whenever a malignancy is suspected.