Introduction: The morbidity and mortality rates associated with appendicitis are greatly increased when perforation ensues, wound infection rates increases, intraabdominal abscess formation increases 15 fold and mortality may be 50 times greater. Ruptured retro-cecal appendicitis can present as extremely fulminant form of a common disease such as extensive retroperitoneal and right thigh abscess. Methodology: This study was performed on 114 consecutive patients who were operated on for clinically and/or radiologically suspected acute appendicitis. All these patients are subjected to diagnostic laparoscopy and appendicectomy. The presence of normal appendix, inflamed, perforated etc. are noted. The diagnosis was also confirmed histopathologically. Results: Alvarado score and CRP in showed sensitivity of 85% and 81% respectively. But TLC showed highest specificity of 100%.CRP shows 73% specificity in our study. 62(54.4%) cases of positive Alvarado score patients showed positive c-reactive protein (CRP) in 53 (85.5%) cases, which shows a significant ‘p’ value of 0.0048. CRP showed positive predictive value of 97%, but it has a low negative predictive value of 29%. Conclusion: Acute appendicitis remains a diagnosis based primarily on history and clinical examination. Serum CRP estimation does not undercut the skill of an experienced surgeon, but compliments it.