Background: Surgical Site Infection rate is an important health care index. Prophylactic antibiotics have been used to prevent surgical site infections. A continuous surveillance is called for to keep a check on the resistance pattern of microbes to the prophylactic antibiotic. Objectives: 1. To estimate the Rate of Surgical Site Infections in the years 2014 and 2015 with reference to CDC guidelines at a tertiary care hospital (PSGIMS&R) located in Tamil Nadu, Southern India 2. To estimate the frequency of various organisms causing Surgical Site Infections 3. To study the antibiotic resistance pattern to the prophylactic antibiotic used. Type of Study: Retrospective Observational study Period of Study: January 2014 – December 2015 Methodology: The present study was conducted in PSG Institute of Medical Sciences & Research, Coimbatore. We did a thorough retrospective analysis of case files of 467patients reported to have culture positive SSI. SSI was established using clinical and Standard microbiological testing. Results: The outcome of this study is that the SSI rate of 4.9% reported in our hospital is consistent with or less than the rates reported in other parts of the country. Diabetes is a very important comorbidity which makes the person significantly vulnerable to SSI. In culture positive cases 24.4% of SSI showed resistance to the prophylactic antibiotic used. Conclusion: There is a significant rise in incidence of organisms exhibiting resistance to the prophylactic antibiotic and a constant surveillance with feedback to the surgeons and strict adherence to antibiotic policies is essential.