Background: The ABO and Rhesus (Rh) blood group systems are the most important human blood group systems and are responsible for most of the blood transfusion reactions, transplant rejections, parental testing and legal purposes. Settings and Design: A retrospective study was conducted at Blood Bank, GMC, Latur, and Maharashtra. A total of 6224 blood donors were studied, during the period from 1st January 2016 to 31st May 2017. Materials and Methods: ABO and Rhesus grouping of the donors were determined using the standard monoclonal antisera by slide agglutination method and reverse grouping. Statistical Analysis: The frequency of ABO and Rh blood group typing was expressed in simple percentages. Results: Out of 6224 donors, 6117(98.28%) were male and 107(1.72%) were female donors. The commonest ABO blood group was B (32.97%) followed by O (30.14%), A (26.38%) and least common AB (10.51%). Among 6224 donors, 298 (4.79%) were Rh negative while 5926 (95.21%) were Rh positive. Conclusion: Our study throws light on the distribution of blood groups in Latur region, which is important for blood banks and transfusion service policies that could contribute to National Health System.

Keywords: ABO; Rhesus; Blood Group; Donors.