Introduction: Cancer is one of the major health issues worldwide including India. Breast cancer is by far the most frequent cancer in females with rising incidence and usually presents at advanced stage at diagnosis making the outcome poor, however aggressive the treatment may be and leading to disproportionately higher mortality rates. Aims and Objectives: To study the age, incidence, clinical presentation and histomorphological pattern of carcinoma breast in all mastectomy specimens. Methodology: Four year retrospective study of 170 mastectomy specimens received in the department of pathology from Jan 2012 to Dec 2016. All the sections were retrieved and diagnosis were confirmed and the necessary clinical data was obtained from records department. Histological grading were done according to Modified Scraff-Bloom-Richardson Method. Results: The commonest presenting symptom was painless lump (65% of patients) with slight left breast predominant involvement (55%). The most common site of location were in upper outer quadrant (35%) and the least in subareolar region (3%). Among the histological varieties invasive duct carcinoma not otherwise specified was the commonest (83%) and the least was tubular carcinoma (0.5%). Majority of the patients were between 41-50 years (45%). 56% of cases showed evidence of metastasis in lymph nodes. In our study, 52.1% of carcinomas were in Grade I, 41.3% were in Grade II, and 6.6% were Grade III. Conclusion: Carcinoma breast is affecting young to middle age group and the number of cases increasing every year and we cannot prevent this cancer, all we can do is Breast Awareness and screening programmes is the need of the hour.

Keywords: Breast; Mastectomy; Infiltrating Duct Carcinoma; Tumor Size; Grade.