Background: Dysfunctional uterine bleeding (DUB) is characterized by abnormal bleeding that is unrelated to any identifiable cause. The aim of this study is to establish that, DUB is a disorder of angiogenesis by detecting vascular endothelial growth factor (VEGF) expression on immunohistochemistry(IHC) study of DUB endometria. Material and Methods: It was a cross section study, undertaken at Index Medical College, Indore over a period of 18 months from March 2015 to July 2016. The study includes 100 endometrial dilation and curettage (D&C) and hysterectomy specimen of clinically diagnosed DUB patients. These specimens were studied for histopathology and expression of VEGF. Results: VEGF expression in endometria of DUB patients was significantly higher than in endometria of control group. There was also significant higher expression of VEGF in endometrial hyperplasia. Conclusion: Significantly over expression of VEGF in the endometrial glands in cases of DUB suggest that VEGF plays an important role in the pathogenesis of DUB

Keywords: DUB; Angiogenesis; VEGF; Endometrium.