Introduction: Skin is a complicated protective covering [1]. It is divided into two seemingly separate but functionally interdependent layers, i.e., epidermis and dermis. Adnexae extend from epidermis into the dermis and consist of specialized cells for hair growth, epithelial renewal (stem cells), and temperature regulation [2]. Epidermis has the capacity to develop an array of keratinocyte lesions, the causes of which are not known. Adnexal tumors may be benign or malignant, solitary or multiple [3]. Aim of the Study: 1. To study the histomorphological features of tumors of epidermis and epidermal appendages. 2. To analyze the clinicopathological features of these tumors. Materials and Methods: This was a 5 years’ study on tumours of epidermis and epidermal appendages, studied i.e., from Jan. 2012 to Dec. 2016. Both biopsies and resected specimens were included in the study. Results: 69 cases of tumours of epidermis and epidermal appendages were encountered, of which, 51 cases (73.91%) were epidermal neoplasms, and 18(26.08%) cases were neoplasms of epidermal appendages. Out of 69 cases, 36(52.17%) were benign neoplasms and 33(47.83%) were malignant neoplasms. The incidence of keratinocytic tumours was high in the present study. Among adnexal tumours, most common were benign sweat gland tumours followed by tumours of hair follicle and sebaceous gland. Malignant adnexal tumours and hematolymphoid tumours were very rare. Conclusion: Skin tumours, at times, may be difficult to diagnose clinically. Hence histopathological examination is a must for definitive diagnosis. Increasing public awareness and surveillance will help in diagnosing the cases early for better management and prognosis.

Keywords: Epidermis; Appendages; Histopathology; Skin and Tumours.