Objective: Blood transfusion is an important mode of transmission of infections to recipients. With every one unit of blood transfusion there is 1% chance of transfusion related complications including Transfusion Transmissible Infections (TTIs). This study was designed to determine the prevalence of Human Immunodeficiency virus (HIV), Hepatitis B, Hepatitis C and syphillis infections among blood donors. Materials and Methods: Total number of 26617 units of blood were collected from healthy voluntary donors and tested for HIV I & II Hepatitis B surface Antigen, Hepatitis C and Syphilis. This study was done during the period of 2011 to 2015 at SBHGMC hospital blood bank, Dhule. Results: It was observed that 33(0.12%) tested positive for HIV, 360(1.35%) were positive for HBsAg,17 (0.06%) were positive for HCV and 13(0.05%) were positive for syphilis. Total 423 Units (1.59%) of blood were discarded due to presence of infective agents. Conclusions: Strict quality control, selection of donors by proper counseling and training of blood transfusion personnel including deferring of suspected donors may help in improving the blood safety.

Keywords: Voluntary; Replacement; Transfusion Transmissible Infections.