Urinary calculi are one of the commonest diseases of urinary tract. The male- female ratio 3:1. 12% of populations have renal calculi in their life time. Mutrala kashaya is propraetary formulation includes 8 drugs & has been pre clinically evaluated as a diuretic & lithotropic activity on wistar rats which showed diuretic activity by increasing urine output by restoring the electrolytes Evaluation of diuretic And lithotropic Activity of Mutrala Kashaya In Wistar Rats therefore a study was planned to evaluate the mutrala kashaya in comparison with varunadi kashaya was undertaken for clinical trial in Mutrashmari. The objective of the present study was to evaluate the efficacy of mutrala kashaya as lithotriptic action w.s.r. urinary calculi ingredients Ushira, Gokshura, Kushmanda. Punarnava, Dhanyaka,Varuna, Kullatha, and Pashanabheda 20-60 years Age group patients Total 30 patients were selected for the clinical study, were randomly divided in two equal and identical groups consisting of 15 patients in each group by using computerized block randomization table. The patients of group ‘A’ and ‘ B’ were given varunadi kashaya and MutralaKashaya 25 ml BD for 45 days were given on 0th, 15th, 30th & 45th day each follow up assessment were done in both the groups. As per the pre and post test was showened significant relief in renal colicky pain, burning micturition, with in physiological range in urinary pH level and reduction in calculi size.

Keywords: Varunadi Kashaya; Mutrala Kashaya; Mutraashmari; Urinary Calculi.