Context: The wound-healing process consists of four highly integrated and overlapping phases: hemostasis, inflammation, proliferation, and tissue remodeling or resolution [1]. Chronic non healing ulcer includes Diabetic foot ulcer (10%-15%), Pressure ulcers (2.7%-9% acute) (2.4%-23% chronic) [2].Treatment of vrana depends on different avastha of vrana and are explained under the heading of shasti upakrama by Acharya Sushruta. Among shasti upakrama, Vimlapanakarma is the preliminary treatment modality for vrana shotha[3]. Aims: To compare the effect of Vimlapanakarma and De-cicatrization on primary intension of healing of Dushtavrana. Materials & Methods: 30 patients fulfilling the inclusion of Dushtavrana were randomly selected and divided into 2 groups, comprising 15 patients in each group. Source of patients were from OPD, IPD of Shalyatantra of KLEU’s BMK Ayurved Mahavidyalaya & Hospital, Belgaum. Control group (De-cicatrization) & Trial group (Vimlapana karma will be done every day continuously for 7 days followed by dressing with Jatyaditaila). Results: Patients treated with de-cicatrization showed difference in pain, size, shape, discharge, smell when compared with Vimlapana group it showed lesser relief in shula and daha. Vimlapana karma has shown significant results within the groups. Statistical Analysis Used: It was analyzed using student t test (paired and unpaired), Mann whitney u test, Wilcoxon signed ranked test and Chi square test, using software graph pad prism version. Conclusion: Vimlapanakarma has shown significant results when compared with De-cicatrization in the parameters like pain, burning sensation & wound contraction (Akruti) in the present study.

Keywords: De-Cicatrization; Dushtavrana; Vimlapana Karma; Wound Healing.